Clonal selection in tamoxifen resistance
نویسندگان
چکیده
منابع مشابه
Tamoxifen Resistance in Breast Cancer
Tamoxifen is a central component of the treatment of estrogen receptor (ER)-positive breast cancer as a partial agonist of ER. It has been clinically used for the last 30 years and is currently available as a chemopreventive agent in women with high risk for breast cancer. The most challenging issue with tamoxifen use is the development of resistance in an initially responsive breast tumor. Thi...
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The anti-oestrogen tamoxifen is the most commonly used treatment for patients with oestrogen-receptor (ER)-positive breast cancer. Although many patients benefit from tamoxifen in the adjuvant and metastatic settings, resistance is an important clinical problem. The target of tamoxifen in vivo is the ER. Over the last decade many advances have been made in our understanding of the biology of th...
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Clonal selection has been a dominant theme in many immune-inspired algorithms applied to machine learning and optimisation. We examine existing clonal selections algorithms for learning from a theoretical and empirical perspective and assert that the widely accepted computational interpretation of clonal selection is compromised both algorithmically and biologically. We suggest a more capable a...
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17β-Estradiol (E2) plays a pivotal role in the development and progression of breast cancer. As a result, blockade of the E2 signal through either tamoxifen (TAM) or aromatase inhibitors is an important therapeutic strategy to treat or prevent estrogen receptor (ER) positive breast cancer. However, resistance to TAM is the major obstacle in endocrine therapy. This resistance occurs either de no...
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To optimize the search of the clonal selection algorithm for the optimal solution, the selection operator is improved and a novel clonal selection algorithm is designed. The selection operator is compared with such selection operators as Roulette Wheel Selection operator, Tournament Selection operator, and Sampling Selection operator. The selection operator is improved to increase the accuracy ...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2010
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.9.9.11952